Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids.
نویسندگان
چکیده
The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.
منابع مشابه
FK 506 in the management of transplant-related nephrotic syndrome and steroid-resistant nephrotic syndrome.
N EPHROTIC syndrome is a broad group of disorders with diverse etiologies. In common. all have proteinuria. edema. hypercholesterolemia. and hypoalbuminemia. Steroids have proven effective in some histologic groups. but many are resistant to steroids and progress to end-stage renal disease. Transplant glomerulopathy and chronic rejection also contribute heavily to renal transplant-related nephr...
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Between January 1, 1989, and December 31, 1994, we have treated 122 primary heart recipients with FK 506 (group I) and 121 with cyclosporine (group II). Fifty patients in the cyclosporine (CyA) group received no lympholytic induction (CyA alone) and 71 others received lympholytic induction with either rabbit antithymocyte globulin or OKT3 (CyA+LI). The mean follow-up was longer in the FK 506 gr...
متن کاملConversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications.
WITH the use of Cy A for clinical liver transplantation, I-year survival rates have approached 70%. Nevertheless, allograft rejection continues to be the most common cause of retransplantation and death. Clinical rejection occurs in 70% ofliver allograft recipients on CyA and steroid therapy. 1 In addition, nephrotoxicity is the principal and dose-limiting side effect of Cy A. Chronic renal dam...
متن کاملRandomized trial in primary liver transplantation under immunosuppression with FK 506 or cyclosporine.
THE USE of cyclosporine (CyA) has greatly impacted the success of liver transplantation. FK 506 is a newly described immunosuppressive agent, with mechanisms of action similar to those of Cy A, but more potent on a weight-ta-weight basis. Pilot studies of FK 506 in primary liver transplantation have shown encouraging results. 1 A randomized trial using FK 506 with low-dose steroids (LDS) was co...
متن کاملLiver, kidney, and thoracic organ transplantation under FK 506.
The new immunosuppressive drug FK 506 was used from the outset with low doses of prednisone to treat 120 recipients of primary liver grafts and 20 more patients undergoing liver retransplantation. The patient survival rate after 2 to 8 months in the primary liver transplantation series is 93.3%, with original graft survival of 87.5%. Of the 20 patients in the hepatic retransplant series, 17 (85...
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عنوان ژورنال:
- Transplantation proceedings
دوره 19 5 Suppl 6 شماره
صفحات -
تاریخ انتشار 1987